Emergency Medicine Residency Program
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Third Year | Research | Simulation
Scholarly Tracks
 

 

Research

Duke Emergency Medicine is on the cutting edge of EM research.  Supported by Duke’s Clinical Research Institute, the largest private research foundation in the US, Duke has ongoing studies in infectious disease, cardiology, stroke, and diagnostic imaging.  Duke Emergency Medicine faculty and residents present nationally at the meetings of the American College of Emergency Medicine and Society for Academic Emergency Medicine.  Our faculty are reviewers for international emergency medicine journals including Annals of Emergency Medicine, Critical Care Medicine, and Emergency Radiology.
 
2008-2009 Research Update 
 
Research Presentations
 
2009 Society of Chest Pain Centers
1.Increasing Stress in Managing Chest Pain in the ED, Abhinav Chandra, Duke University Medical Center, Society of Chest Pain Centers, Memphis, April 2009

2. Comparison Of Adverse Drug Events In Observation Units To Emergency Departments, Abhinav Chandra, Duke University Medical Center, Society of Chest Pain Centers, Memphis, April 2009
 
3.Emergency Department Observation Unit Improves Patient Satisfaction Press Ganey Scores, Abhinav Chandra, Duke University Medical Center, Society of Chest Pain Centers, Memphis, April 2009 – ORAL Presentation Plenary Session
 
4. Impact of Mode of Arrival on Door-to-Balloon Times, Akhil Saraswat, Duke University Medical Center, Society of Chest Pain Centers, Memphis, April 2009
 
2009 Emergency Nurses Association
 
5.Ultrasound-Guided Venous Cannulation by the Emergency Nurse, Fernando Lopez, Duke University Medical Center, ENA, Baltimore, October 2009
 
6.Increasing Stress in Managing Chest Pain in the ED, Abhinav Chandra, Duke University Medical Center, ENA, Baltimore, October 2009
 
7. Service Excellence as a Way of Life in the ED, Ann White, Duke University Medical Center, ENA, Baltimore, October 2009
 
8. Actualizing Homeland Security Goals in the ED Through Hazmat Training, Ann White, Duke University Medical Center, ENA, Baltimore, October 2009
 
9. Impacting Safe Medication Administration and Glycemic Control through Diabetes Education, Ann White, Duke University Medical Center, ENA, Baltimore, October 2009
 
2009 Duke Research Presentation
 
10. Abdominal CT Limited to the Region of Tenderness Can Accurately Detect Acute Pathology While Substantially Reducing Radiation Exposure: a Prospective Double-Blinded Study, Joshua Broder, MD
 
2009 National SAEM
 
11. Female Gender And Obesity Associated With Decreased Odds Of Successful Intramuscular Epinephrine, Craig Mangum, MD, Duke University Medical Center, SAEM, New Orleans, May 2009  
 
12. Voluntary Use of NEXUS Criteria in an Electronic Emergency Department Information System is Not Associated with Decreased Use of Cervical Spine Imaging, Joshua Broder, MD, Duke University Medical Center, SAEM, New Orleans, May 2009, (Plenary--Oral)
 
13. Detectable Troponin Levels In Low Risk Chronic Kidney Disease Patients Increase Risk For Acute Coronary Syndrome, Alexander Limkakeng, MD, Duke University, SAEM, New Orleans, May 2009  
 
14. Abdominal CT Limited to the Region of Tenderness Can Accurately Detect Acute Pathology While Substantially Reducing Radiation Exposure: a Prospective Double-Blinded Study, Joshua Broder, MD, Duke University Medical Center, SAEM, New Orleans, May 2009, (Plenary--Oral)
 
15. Cardiac Evaluation for Structural Abnormalities May Not Be Required in Patients Presenting with Syncope and a Normal Electrocardiogram, Kenton Anderson, MD, Duke University School of Medicine, SAEM, New Orleans, May 2009  
 
16. 80 Lead ECG Body Surface Mapping Detects More High Risk ECG Abnormalities in ED Patients with Acute Coronary Syndromes: Results from the OCCULT MI Trial, James Hoekstra, MD, Wake Forest University Health Sciences, SAEM, New Orleans, May 2009 (Plenary--Oral)
 
2009 Regional SAEM Presentations
 
17. Cardiac Evaluation for Structural Abnormalities May Not Be Required in Patients Presenting with Syncope and a Normal Electrocardiogram -- Anderson & Chandra
 
18. Abdominal CT Limited to the Region of Tenderness Can Accurately Detect Acute Pathology While Substantially Reducing Radiation Exposure: a Prospective Double-Blinded Study -- Broder
 
19. Detectable Troponin Levels In Low Risk Chronic Kidney Disease Patients Increase Risk For Acute Coronary Syndrome -- Story & Limkakeng
 
20. Voluntary Use of NEXUS Criteria in an Electronic Emergency Department Information System is Not Associated with Decreased Use of Cervical Spine Imaging -- Ochello & Broder
 
21.Emergency Department Obserrvation Unit Improves Patient Satisfaction Press Ganey Scores -- Chandra
 
22. A Multi-Centered Assessment of Pneumonia Signs and Symptoms in Patients with Alternate Discharge Diagnosis -- Chandra
 
23. A Comparison Of Adverse Drug Events In Observation Units To Emergency Departments -- Chandra
 
24. Screening for Left Ventricular Abnormality with Electrocardiograph and NT-proBNP in Patients with Hypertension -- Chandra
 
2008 ACEP Presentation
 
25. Broder JS, Uppal A, Finnegan B, Meyer J.  A Randomized Controlled Trial of Two Online Methods for Interpretation of Computed Tomography of the Head.  American College of Emergency Physician, Chicago, Il, October 2008.
 
26. Limkakeng AT Jr, Saraswat A, Glickman S, Molinar G, Drkae W, Freeman, DH, Chandra A.  Blood Pressure Response in Hypertensive Emergency Department Patients with a History of End Organ Disease.  American College of Emergency Physician, Chicago, Il, October 2008.
 
27. Kim ET, Glickman SW, Phillips S, Kraft M, Limkakeng AT, Chandra A, Cairns CB.  Delays and High Costs Associated with Emergency Physician Variation in Diagnostic Approaches to Venous Thromboembolism.  American College of Emergency Physician, Chicago, Il, October 2008.
 
28. Glickman SW, Phillips S, Kim ET, Preston R.  Increases in Central Venous Catheterization among Community Emergency Department Visits from 2004-2008.  American College of Emergency Physician, Chicago, Il, October 2008.
 
29. Phillips S, Glickamn SW, Stanley LJ, Preston  RJ, Grant GA, Laskowitz DJ, Cairns CB.  C-reactive Protein as a Serum Biomarker in the Evaluation of Patients with Minor Head Injury and Normal Mental Status in the Emergency Department.  American College of Emergency Physician, Chicago, Il, October 2008.
 
30. Limkakeng AT Jr, Glickman SW, Greene V, Chandra A.  Incidence and Impact of Renal Dysfunction on Acute Coronary Syndrome in Chest Pain Observation Unit Patients.  American College of Emergency Physician, Chicago, Il, October 2008.
 
31. Weeds S (MS) et al.  National Patterns in Emergency Department Antibiotic Prescribing for Elderly Patients with Urinary Tract Infections, 1996-2005.   American College of Emergency Physician, Chicago, Il, October 2008.
 
32. Adhikari S, Raio C, Theodoro D, Morrison D, Leech S, Meer J, Tsung J, Lyon M, Akhtar T, Lopez F.  Emergency Medicine Residents' Attitudes Regarding Ultrasound Guided Central Venous Catheterization.  American College of Emergency Physician, Chicago, Il, October 2008. 
 
33. Adhikari S, Raio C, Morrison D, Leech S, Meer J, Tsung J, Lyon M, Akhtar T, Lopez F.  Emergency Medicine Residents’ perceptions of Ultrasound Education.  American College of Emergency Physician, Chicago, Il, October 2008.
 
34. Lavonas E J, Kerns WP III, Gerardo CJ, Richardson W, Whitlow K, Berkoff DJ.  Long-Term Limb Function Outcomes after Copperhead Snakebite.  American College of Emergency Physician, Chicago, Il, October 2008.
 
 2008 Society of Chest Pain Centers
 
35. Chandra A, Peacock WF, et al.  Society of Chest Pain Centers Accreditation Improves ACC/AHA Guidelines compliance for NSTEMI.  Society of Chest Pain Centers, Orlando, FL, April 2008. (Plenary)
 
 2008 National SAEM
 
36. Ndubuizu A, ….Wide Variability in the Consent Process For Non-English Speaking Subjects.  Acad Emerg Med 2008 (in press).  Society for Academic Emergency Medicine Annual Meeting, Washington, D.C., 2008.
 
37. Limkakeng A, … Treatment of Hypertensive Emergency Department Patients with Renal Dysfunction. Acad Emerg Med 2008 (in press).  Society for Academic Emergency Medicine Annual Meeting, Washington, D.C., 2008.
 
38. Cairns C, …. Asthmatic Inflammatory Response to Mycoplasma Pneumoniae Infection Is Linked To Impaired Surfactant Protein a Function.  Acad Emerg Med 2008 (in press).  Society for Academic Emergency Medicine Annual Meeting, Washington, D.C., 2008.
 
39. Phillips S, … A Novel Biomarker Panel Distinguishes Stroke from Mimics in the Emergency Department.  Acad Emerg Med 2008 (in press).  Society for Academic Emergency Medicine Annual Meeting, Washington, D.C., 2008.
 
40. Philips S, … Initial D-Dimer Level Predicts Severity and Death in ED Patients with Stroke.  Acad Emerg Med 2008 (in press).  Society for Academic Emergency Medicine Annual Meeting, Washington, D.C., 2008.
 
 
Manuscripts
 
  1. Chandra A, Otero R, Freeman D, Cairns CB: BNP-mediated vasodilatation for dialysis-dependent patient with acute heart failure in the emergency department. Ren Fail 2008; 30(1) :45-50.
 
  1. Kraft M, Adler KB, Ingram JL, Crews AL, Atkinson TP, Cairns CB, Krause DC, Chu             HW:  Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC preferentially in asthma. Eur Respir J 2008; 31(1) :43-6.
 
  1. Glickman SW, Anstrom K, Li L, Chandra A, Laskowitz D, Woods C, Freeman D, Kraft          M, Breskow L, Weinfurt K, Schulman K, Cairns CB: Challenges in enrollment of minority, pediatric and geriatric patients in emergency and acute care clinical research. Ann Emerg Med 2008 Jun;51(6):775-780
 
  1. Piehl MD, Manning JE, McCurdy SL, Rhue TS, Kocis KC, Cairns CB, Cairns BA:  Pulse        contour cardiac output analysis in a piglet model of severe hemorrhagic shock. Crit Care Med 2008, 36:1189-1195
 
  1. Glickman SW, Schulman KA, Hocker MB, Peterson ED, Cairns CB: Evidence based perspectives on quality of care and patient outcomes in emergency medicine. Ann Emerg Med 2008; 51: 775-780. 
 
  1. Clem KJ, Promes SB, Glickman SW, Shah A, Finkel MA, Pietrobon R, Cairns CB : Factors enhancing career satisfaction among female emergency physicians. Ann Emerg Med 2008; 51: 723-28.
 
  1. Glickman SW, Schulman KA, Peterson ED, Hocker MB, and Cairns CB.  Evidence-based perspectives on pay for performance and quality of patient care and outcomes in emergency medicine. Annals of emergency medicine. 2008 May;51(5):622-31.
 
  1. Peacock WF, Ohman M, Chandra A, Januzzi JL, Bhatt D.  "Cardiologist and Emergency Physician Perspectives and Knowledge of Reperfusion Guidelines in ST-Segment Elevation Myocardial Infarction."  Texas Heart Institute Journal.  2008; 35 (2): 1-10. 
 
  1. Zimmerman LI, Lima R, Pietroban R, Marcozzi D.  The effects of seasonal variation on hazardous chemical releases.  Journal of Hazardous Materials 2008; 151: 232–238.
 
  1.  Broder JS.  Comments on "sensitivity of noncontrast cranial  computed tomography for the emergency department diagnosis of subarachnoid hemorrhage".  Ann Emerg Med. 2008 Dec;52(6):767-8.
 
  1.  Broder JS.  CT utilization: the emergency department perspective.  Pediatr Radiol. 2008 Nov; 38 Suppl 4:S664-9
 
  1.  Singer AJ, Birkhahn RH, Guss D, Chandra A, Miller CD, Tiffany B, Levy P, Dunne R, Bastani A, Thode HC Jr, Hollander JE. Rapid Emergency Department Heart Failure Outpatients Trial (REDHOT II): A RCT of the Effect of Serial BNP Testing on Patient Management.  Circ Heart Fail (Accepted for Publication: MS #: 2008-826685 – April 2009)
 
  1.  Chandra A, Nicks B, Maniago E, Nouh A, Limkakeng A.  A Multicenter Analysis of the Emergency Department Diagnosis of Pneumonia.  American Journal of Emergency Medicine.  2009 (Accepted for Publication) DOI:10.1016/j.ajem.2009.04.014
 
  1.  Chandra A, Lindsell C, Limkakeng A, etc  Emergency Physician High Pre-test Probability for Acute Coronary Syndrome Correlates with Adverse Cardiovascular Outcomes.  Academic Emergency Medicine.  2009 (Accepted for publication -- AEMJ-09-038.R1)
 
  1. Gerardo C, Chandra A, Glickman S…  The rapid impact on mortality rates of a dedicated care team including trauma and emergency physicians at an academic medical center.  Journal of Emergency Medicine. 2009; (Accepted for Publication)
 
  1. Limkakeng Jr. AT and Abhinav Chandra.  Impact of Renal Dysfunction on Acute Coronary Syndrome Evaluation in Observation Unit Patients.  American Journal of Emergency Medicine.  2009; (accepted for Publication—In Press)
 
  1. Chandra A, Cairns CB, Peakcock FA, McCord JM, Gibler B, Peterson ED, Roe M: Society of Chest Pain Centers accreditation improves ACC/AHA Guidelines compliance for NSTEMI. Ann Emerg Med.  2009 (In Press) doi:10.1016/j.annemergmed.2009.01.025     
 
  1. Limkakeng Jr. AT, Glickman SW, Cairns CB, Chandra A (Senior Author): Unsuspected pulmonary embolism in observation unit patients.  Western Journal of Emergency Medicine 2009 (Accepted for Publication). 
 
2009 ED Site Research Projects
 
  1. CAPSOD: Plasma protein Biomarker-Based Diagnostics Of Outcome In Sepsis and community acquired pneumonia. (NIH)
 
  1. Assessment of Microfluidic PCR platform to detect microbial DNA in patients with suspected community acquired pneumonia. (NIH)
 
  1. PROCESS – Comparison of Outcomes in Patients with Sepsis and Goal Directed Therapy. (NIH)
 
  1. Dade -- D-dimer exclusionary study of venous thromboembolism.
 
  1. Metabolomic and Biomarker Profiles in patients with acute head injury.
 
  1. PRESSURE:  Assessment of cardiac function in patients with hypertension.
 
  1. OCCULT-MI:  Assessment of 80-lead electrocardiogram in patients with chest pain.
 
  1. Phase III Trial of Crofab in Copperhead envenomations.
 
  1. HIV Screening in Emergency Department.
 
  1. Chronic Back Pain Survey Trial
 
  1. CLUE – Comparison of Labetolol to Nicardipine for Hypertension
 
  1. PRONTO – Evaluation of Clevidipine in Hypertensive Emergency and Acute CHF.
 
  1. Astella – Evaluation of Treatment of Hyponatremia in CHF.
 
  1. ALIAS: Albumin in acute stroke.
 
  1. Non-invasive evaluation of Intracranial pressure with Ultrasound and  Ocular Pressure Device.
 
  1. Use of Daptomycin in Pediatric Patients with soft tissue infections.
 
  1. Evaluation of use of Ultrasound to assess pulmonary edema in CHF.
 
  1. Registry of Out of Hospital Cardiac Arrests.
 
  1. Evaluation of Efficacy of limited CT of Abdomen based on physical exam findings.
 
  1. BIMIPP: Phase II trial of novel nuclear imaging agent for acute cardiac ischemia.
 
  1. CLOSURE:  Phase III trial of novel tissue adhesive in Emergency Department patients.
 
  1. Development of non-invasive tissue perfusion measurement device.
 
Faculty & Resident Involvement
 
A Chandra
A Limkakeng
J Broder
V Thornton
L Ragsdale
F Lopez
C Gerardo
D Gordon
S Stahmer
C Mangum
K Lewis
K Anderson
A Saraswat
L Zimmerman
D Story
C Ochello
E Damuth
L Southerland
 
Grant Applications
 
Limkakeng & Chandra – NIH Challenge Grant on Biomarkers and Stress Testing
Broder & Chandra – NIH Challenge Grant on CT Abdomen
Laskowitz & Chandra – NIH Challenge Grant on Brain Injury
Ragsdale – Foundation Grant – Evaluate Geriatrics at Fall Risk
 
 
 
 
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